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It was developed from research into Epithalamin, a complex peptide extract originally obtained from bovine pineal tissue

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The figure is demonstrating predicted pharmacokinetic features of compounds: passive gastrointestinal absorption (HIA), passive brain access (BBB) and active efflux from the central nervous system or to the gastrointestinal lumen by P-glycoproteins (PGP+: yes, PGP-: no) based on physicochemical descriptors (WLOGP and TPSA, for lipophilicity and apparent polarity)

Ingredients Water added to carbon dioxide, sugar, glucose syrup, acidifier: citric acid, tartaric acid, taurine (0.4%), flavors, flavor enhancer: erythritol, acidity regulator: hydrogen sodium carbonate, magnesium carbonate, preservatives: sorbic acid, benzoic acid, caffeine (0.03%), ulcorants: sweets alose

Supplementary Table 1 (download XLSX Screen data

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