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In the published clinical literature on the reference drug (for example the STEP-1 extension study of semaglutide), discontinuing a GLP-1 receptor agonist is followed by the return of appetite signalling and gradual regain of much of the lost body weight over roughly a year, because the receptor stimulation that slowed gastric emptying and curbed appetite is withdrawn

At the University of California, Santa Barbara, says 22-year-old student Ryan Roberts, "everybody does them." The long-term health risks of this experimentation are not yet known, but doctors are worried about higher cancer risk