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Have certain medical conditions: Problems that can restrict vitamin B12 absorption include pernicious anemia (a rare autoimmune disease that keeps the body from making a protein necessary to absorb B12), digestive illnesses, such as celiac and Crohns diseases, and immune disorders such as lupus, among others

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However, tesofensine seems to enhance the recruitment of LH neurons exhibiting activation after drug administration (i.e., see E4 neurons in Fig 2 )

Vitamin B12 deficiency may cause pins and needles in the hands or feet

These are rare