(2022) utilized anthocyanins extracted from black beans to treat type 2 diabetic mice, activating AMPK in skeletal muscle cells to improve glucose utilization and decrease gluconeogenesis, while concurrently down-regulating phosphoenolpyruvate carboxykinase (PEPCK) and glucokinase (GK) activitiescrucial enzymes in glycolysis that boost intracellular glucose catabolism
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This is a fundamental limitation of the enterprise: the arithmetic is exact, but its inputs are uncertain, so an exact calculation on an uncertain input yields an uncertain result dressed up in false precision
doi: 10.1093/ajcn/nqab402
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Its synergistic triple-agonist mechanism distinguishes it from older incretin-based therapies and makes it a focus of research into advanced obesity and metabolic treatments
