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FIGURE 4 This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology ( As many treatments for neurological conditions have been hampered by limited permeability of the BBB, significant emphasis has been placed on research directed towards advanced drug delivery methods (Zha et al., 2024

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Chari RV

Liver tissue from Gclc L-KO mice showed enrichment of NRF2 protein and downstream target genes (Fig

Choline plays a role in lipid transport and metabolism, working synergetically with methionine and inositol

The methodology included database searches, keyword selection, and eligibility screening