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Intestinal flora modulates blood pressure by regulating the synthesis of intestinal-derived corticosterone in high salt-induced hypertension [J]

This has a number of harmful consequences and puts people at risk for heart, kidney, eye, and brain disease including heart attack, peripheral arterial disease, stroke, loss of vision, and kidney failure

The goal is to minimize inappropriate mediator release and reduce baseline reactivity

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It predisposes affected individuals to tumors of the thyroid (medullary thyroid carcinoma), adrenal glands (pheochromocytoma), and parathyroid glands

Semaglutide carries a boxed warning against use in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)