If oral bioavailability is low (1030%, similar to some quaternary ammonium compounds), a much higher oral dose would be required to match the plasma exposure achieved with subcutaneous injection
Mechanisms of resistance to three mite growth inhibitors of Tetranychus urticae in hops
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Bollinger, L
10.1007/s00706-005-0330-y Monatsh
First, a bacterial reverse mutation test (Ames test) assessed AOD9604s mutagenic potential using four histidine-dependent auxotrophic mutants of Salmonella typhimurium (TA1535, TA1537, TA98, TA100) and one tryptophan-dependent auxotrophic mutant of Escherichia coli (WP2 uvrA), using both plate incorporation and pre-incubation methods at doses of 0, 1.6, 8, 40, 200, 1,000, and 2,000 g AOD9604/plate