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PMID: 18728176 Messenger AG, McKillop J, Farrant P, McDonagh AJ, Sladden M

As an example, platelets from G6PD-deficient individuals exhibit reduced G6PD enzymatic activity (30), affecting the availability of reduced glutathione required for platelet aggregation (89) and of NADPH needed for biosynthesis of fatty acids and phospholipids (90) ( Figure 1A-3 )

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CMLS Cell Mol Life Sci

This conformational restriction prevents the peptide from adopting flexible substrate orientations that proteases require for efficient cleavage

Further research is needed both in healthy and disease states to determine the critical role that the microbiota and diet may play in the progression of disease