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One example of such GPCR is the protease-activated receptor 2 (PAR2), which is specifically expressed in the plasma membrane of endometrium epithelial cells and modulates intracellular calcium levels upon activation by serine proteases like trypsin

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Wilson CG, Tran JL, Erion DM, Vera NB, Febbraio M, Weiss EJ (2016) Hepatocyte-specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice

Why Im cautious: The human efficacy story is not in the same league as GLP-1 evidence

However, vaccines that limit disease still have benefits, as they prevent infections from causing severe disease and death

10.3389/fonc.2020.00949 Front