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"We should note, however, that the definition of LV enlargement proposed by both the EPIC trial and, subsequently, by the ACVIM Consensus panel, is not a reference value, but a somewhat arbitrarily chosen threshold for inclusion in the EPIC trial

This localized delivery and high gastric concentration may exert direct, proximity-dependent effects on the upper gastrointestinal microbiota and local epithelial barrier integrity before systemic absorption, a feature completely absent in injectable regimens

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