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Additionally, the hepatic isoform alpha of the liver X receptor (LXR) is required for SREBP1c phosphorylation in a separate mechanism

Kunitomi M, Wada J, Takahashi K, Tsuchiyama Y, Mimura Y, Hida K, Miyatake N, Fujii M, Kira S, Shikata K, Maknio H

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"The increased use of GLP-1 medications presents an exciting opportunity to support Americans managing diabetes and weight loss, as well as those seeking to lead a healthier lifestyle," said Bob Nolan, vice president, Demand Science at Conagra Brands

This process induces oxidative stress and lipid peroxidation, accelerating ferroptosis and driving the progression of OA