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The dysregulation of the transsulfuration pathway could result in higher homocysteine levels and lower cysteine and taurine levels.[ref] Related article: Osteoporosis Depression: Higher levels of homocysteine are found in people with major depressive disorder, on average

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Increase in water reabsorption In a spontaneous hypertensive rat model, TMAO increased plasma osmotic pressure and water reabsorption via the TMAO-AVP-(AQP-2) axis, which contributed to hypertension (121)

Height and weight are used to calculate BMI

The mechanisms don't overlap