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[10] None of that translates to established human dosing, safety margins, or confirmed bioavailability via injectable routes

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The peptide Bremelanotide PT-141 is now FDA approved to treat sexual dysfunction in women

SGLT2 brain expression is lower compared to SGLT1, and it is localized mainly in the microvessels of the blood-brain barrier, in the amygdala, hypothalamus, periaqueductal gray, and in the dorsomedial medulla (Enerson and Drewes, 2006)

Efficacy endpoints were change from baseline in HbA 1c and body weight (and, for the separate PIONEER 8 subgroup analysis, change from baseline in insulin dose) at the planned end of treatment (weeks 26, 52 or 78, according to the trial)

So were gonna have to get boosters