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In addition, mtROS can also directly act on some proteins on the mitochondrial matrix or mitochondrial membrane, and regulate the activity of mitochondrial complex I, complex III, and complex IV through Toll-like receptors, retinoic acid-inducible gene I-like receptors and other signaling pathways, thereby affecting OXPHOS

& Voet, J

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Exosomes, or extracellular nanovesicles, and peptides, small strings of amino acids, have shown promise as topical therapies in early trials, but neither is FDA approved

The DNA methylation is an epigenetic mechanism, able to modify the expression of specific genes without changing the DNA sequence

it is a bio-delivery method that ensures the "master antioxidant" is delivered more efficiently