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The lyophilization processbasically, sophisticated freeze-dryingremoves the water, which dramatically slows down these chemical reactions, putting the molecule into a state of suspended animation

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These PPP abnormalities ultimately impact cellular function: for example, neutrophils in COPD patients primarily rely on glycolysis for energy, with both the PPP and glycolysis supplying energy and NADPH for the formation of neutrophil extracellular traps (NETs)

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