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12 Furthermore, postmarketing reports of acute pancreatitis, both fatal and nonfatal hemorrhagic and necrotizing, and rare hypersensitivity reactions such as angioedema and Stevens-Johnson syndrome may limit use in certain populations

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I will tell you, in the phase three trials, anywhere from 8 to 15% of individuals in the trials so we know they're taking the drug do not lose at least 5% of their body weight

Methods Animal studies All experiments were performed under the UK Home Office project licence PE50F6065 in accordance with the UK Animals (Scientific Procedures) Act, 1986, and approved by the University of Cambridge Animal Welfare and Ethical Review Body

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