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Mounjaro (tirzepatide) injection still leads on magnitude, with around 20% average weight loss at the highest dose when paired with lifestyle support

The FDA has approved a number of peptides as medications, including insulin for diabetics who dont naturally produce it and human growth hormone for children with developmental disorders caused by low levels of the hormone

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SGLT2 inhibitors (sodium-glucose cotransporter-2 inhibitors) include medications like Jardiance (empagliflozin) or Farxiga (dapagliflozin)

Muscle mass decreases at an accelerating rate, a process called sarcopenia, and since muscle tissue burns more calories than fat tissue, this compounds the metabolic slowdown