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A common dose is 1000 mcg daily, given either intramuscularly (IM) or subcutaneously
So, if you ask yourself, "why B12 shots are better than oral supplements?" - you know that injections have a much higher and quicker response time than ingestion
The mechanism is proposed to involve G-protein coupled receptor signaling, but definitive identification of the functional receptor has not been published
The needle is very short (think insulin syringes), and doesnt go beyond the fat tissue
[1] Most often for at-home therapy, it will be IM injections
PMID: 29543316 5 Bioavailability and daily requirement of vitamin B12 in adult humans: an observational study of its colonic absorption and daily excretion as measured by [13C]-cyanocobalamin kinetics
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