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Similarly in bone metastatic prostate cancer, miR-19a-3p downregulation promotes an oncogenic phenotype [97]

In an in vivo study to evaluate anti-osteoarthritis activity in an osteoarthritis rat model induced by monosodium iodoacetate, the extract at 150 or 300 mg/kg reduced proinflammatory cytokine and mediator release, prevented cartilage degradation, and attenuated joint pain

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Examples of otoprotectants include, but are not limited to, PNU 37883, AM 92016, XE-991, linopirdine, Ro 04-5595, ()-1-(1,2-diphenylethyl)piperidine, ifenprodil, SYM 2206, FPL 64176, ZK 93423, m-chlorophenylbiguanide, 2-APB, MR 16728, d-tubocurarine, berbamine, E6 berbamine, hernandezine, and isotetrandrine