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doi: 10.1128/mbio.01108-25

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While eCOA has been used for decades, its expansion at scale has introduced new complexity, as expectations for automation and performance have outpaced the underlying processes and scientific oversight required to support them

This connection to an endogenous protective factor, combined with the breadth of preclinical research showing activity across multiple physiological systems, has contributed to the peptide's popular attention

TB-500 is the synthetic tetrapeptide fragment Ac-SDKP, corresponding to the actin-binding domain of thymosin beta-4