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This is the same cost-effectiveness barrier that has kept all obesity medications off provincial formularies since orlistat in the early 2000s

Liraglutide's protective effect was further verified in the anterior cruciate ligament (ACL) rat model, in which sub-cutaneous injection of liraglutide 50 g/kg/day for 3 or 6 weeks decreased the number of caspase 3- and CHOP-positive cells in cartilage [35]

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