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Nat Chem Biol 16:497506 Gaschler MM, Andia AA, Liu H, Csuka JM, Hurlocker B, Vaiana CA et al (2018) FINO(2) initiates ferroptosis through GPX4 inactivation and iron oxidation

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Even in women with functional GSTM1 and GSTT1 genotypes, depleted GSH levels reduce conjugation capacity

These findings highlight the complexity of metformins effects, which may be age-, genotype-, and disease-context dependent, reinforcing the need for further experimental and clinical validation to clarify its therapeutic potential and risks in AD prevention across different populations

NADPH, nicotinamide adenosine dinucleotide phosphate

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