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That year, the Food and Drug Administration greenlit Novo Nordisks semaglutide-based drug Wegovy as an obesity treatment after clinical trials showed users lost an average of 15% of their body weight over 16 months

Ann N Y Acad Sci 1258:2533

One such drug, Ozempic, has recently dominated the market due in large part to its ability to help users lose weight

More than 30 million Americans will be on GLP-1 treatment in 2030, according to an estimate from JP Morgan.

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While tirzepatide has yet to demonstrate direct cardiovascular risk outcomes in patients without type 2 diabetes, tirzepatide-treated groups did demonstrate reductions in cardiometabolic variables resulting in a significantly lower 10-year predicted ASCVD risk in patients with overweight or obesity without type 2 diabetes in post hoc analysis of the SURMOUNT-1 trial [49]