doi:10.3390/biomedicines9060609 Hsieh MJ, Lee CH, Chueh HY, et al
This one report is certainly most interesting, but needs confirmation before this treatment can be suggested for general application (108.1)
The molecule is small enough to cross the epidermal barrier to some degree, but reaching fibroblasts in the mid-to-deep dermis where the structural work happens requires either injection or a delivery mechanism that bypasses the barrier

For starters, some research has found that ginger may decrease blood clotting and could interfere with blood thinners when used in high amounts ( Because ginger may impact blood sugar levels, those taking medications to lower their levels may also want to consult with their healthcare provider before taking supplements ( Additionally, keep in mind that turmeric powder is made up of only about 3% curcumin by weight, so you would need to consume a very large amount or use a supplement to reach the dosage found in most studies ( In high doses, curcumin has been associated with side effects like rashes, headaches, and diarrhea ( Finally, though research on the potential health effects of both ginger and turmeric is plentiful, evidence on how the two may affect health when used together is limited
A review in the International Journal of Molecular Sciences described GHK-Cu as able to reset gene expression to a healthier, more youthful state in damaged or aged cells
S10) reflect that the models barrier integrity was not changed during the nanocarrier permeability experiment confirming the robustness of the model and the accuracy of the assay