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Glucose-dependent actions of GLP-1 The incretin hormone GLP-1, released by the gut in response to food intake, acts on beta and alpha cells in the pancreatic islets to increase insulin secretion and decrease glucagon secretion, respectively

doi: 10.1210/jcem.81.12.8954048 18 OblFJr.PayneLOppMAlfldiPKapsLKruegerJM

This reduction in calorie intake, and subsequent weight loss, is believed to be caused by a decrease in appetite and cravings and a reduction in cravings for high-fat foods