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This can only be done under proper medical supervision to manage potential side effects and avoid unwanted results like Ozempic face or muscle loss

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Jan-Apr 2020;28(2):2309499020905993

For example, a patient who cannot tolerate or does not respond to a GLP-1 receptor agonist might be switched to naltrexone-bupropion or orlistat, depending on individual circumstances and contraindications