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If A1C levels remain above goal after three months of therapy, a second agent should be added (e.g., sulfonylurea, thiazolidinedione, dipeptidyl-peptidase-4 inhibitor, glucagon-like peptide-1 receptor agonist, insulin)
The copper component serves as an essential cofactor for lysyl oxidase and lysyl hydroxylase, enzymes critical for proper collagen cross-linking and stability
5 , e221169e221169 (2022)
However, there may be exceptional circumstances where dose escalation is delayed, such as: Significant gastrointestinal side effects that have not resolved after one month Concurrent acute illness or hospitalisation Patient preference to extend the titration period under medical supervision Concerns about tolerability in frail or elderly patients Healthcare professionals should review patients after starting Rybelsus to assess tolerability, reinforce dosing instructions, and plan dose escalation
[DOI] [PubMed] [Google Scholar] 48.Tsai CF, Wu JY, Hsu YW
