To advance translational applications, future studies should focus on: (1) transforming dynamic biomarkers into clinical decision-making tools, such as evaluating early changes in circulating mitochondrial-derived vesicles or oxidative stress markers (e.g., 8isoprostaglandin F2 (8-iso-PGF2))to predict subsequent biochemical and histological responses
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A careful medical history is essential
Deletion of SLC25A39 was embryonically lethal at day E13.5 and embryos appeared pale, suggesting a severely anemic phenotype (Extended Data Fig
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