Metabolism The primary route of elimination for semaglutide is metabolism following proteolytic cleavage of the peptide backbone and sequential beta-oxidation of the fatty acid sidechain

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TABLE 3 Intra-day and inter-day precision of PA, PB, PC, PE, GAS, and 4-HBG in plasma and brain tissue (n = 6)
Aliquoting and freezing at -20C extends this timeline