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GLP-1 agonists promote the release of insulin in response to hyperglycaemia, inhibit the secretion of glucagon, slow gastric emptying, and augment satiety by directly affecting the central nervous system 1

The modest yet statistically significant alterations in CSF biomarkers of inflammation and tau pathology indicate that semaglutide reaches the brain and exerts some biological effect

For that reason, dose strategy should consider systemic hormonal status rather than symptom relief alone

Bettini S, Bordigato E, Fabris R, Serra R, Dal Pra C, Belligoli A, et al