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This article focuses specifically on cost

The potential for small molecules to inhibit these pathways and non-selectively inhibit GHR signaling needs to be considered in small molecule discovery studies

The trade-off is convenience versus shelf life flexibility

The realistic caveat is that long-term maintenance without pharmacologic or procedural support is difficult for most people which is the entire reason the rest of this list exists

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For example, a much smaller patient will need a lower dose, whereas someone with greater body mass or a resistance to the medication will likely need a higher one