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The adenosine binding pocket is strikingly similar, with the ribose moiety stacking with the conserved Trp61 residue and forming a network of polar interactions linking across the dimer interface via the conserved Glu71-His72 motif (Figs

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Interestingly, Day 45 organoids exhibited a shift toward a mesenchymal cell profile, with increased markers of hepatic stellate cells, suggesting utility for disease modeling applications

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