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Effect of ovarian steroids Variations in E2 and P4 influence carbohydrate and lipid metabolism through coordinated effects on insulin sensitivity, glucose transport (e.g., GLUT4 translocation), hepatic glucose output, lipolysis, fatty acid oxidation, and mitochondrial efficiency [8,42,43,44,45,46]

While the loss of GSH does not cause liver failure, it decreases lipogenic enzyme expression, circulating triglyceride levels, and fat stores

Increasing their supplemental intake may cause less oxidative damage in diabetic patients and also help reduce insulin resistance (x)

doi: 10.1074/jbc.M709040200 276 ThorleyA

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Adequate dietary intake of copper is therefore essential for the optimal function of lysyl oxidase and the maintenance of strong collagen networks within the ACL