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Low-purity peptides often contain residual salts, synthetic byproducts, or other contaminants

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Multiple controlled trials using indirect calorimetrythe gold standard for measuring energy expenditurehave demonstrated that GLP-1 therapy does not elevate RMR beyond what would be expected from changes in body composition

Reports include severe side effects like nausea, vomiting, and even hospitalization due to dosing errors and improperly labeled products

doi: 10.1016/j.cmet.2019.03.002 61 GrunddalKVJensenEPrskovCAndersenDBWindelvJAPoulsenSSet al

Examples include: Coronary artery disease (CAD) History of myocardial infarction Prior stroke Peripheral artery disease (PAD) Documentation is usually required