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2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5549431/, Huang, Zong-Zhi, et al

The disease process of hypothyroidism-induced NAFLD therefore appears to involve both intrahepatic and extrahepatic factors, with important differences between mild (subclinical) and severe hypothyroidism

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In 2015, administration of Setmelanotide to obese individuals for a limited time increased resting energy expenditure (REE) by 6.4% and shifted substrate oxidation to fat (29)

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Li H, Du J