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Mitochondrial dysfunction and ROS Reactive oxygen species (ROS) are highly reactive molecules with a free oxygen that easily react with other molecules

This systems activity declines with aging, and GHK-Cus restoration of proteasome function likely contributes to its anti-aging effects at the cellular level

Research Applications Preclinical research has demonstrated that NNMT inhibition with 5-Amino-1MQ reduces adipogenesis, decreases fat cell size, and increases resting metabolic rate in animal models without significant toxicity

Yang J, Yang J, Huang X, Xiu H, Bai S, Li J, et al

The absence of a head-to-head trial means that prescribing decisions will initially be guided by availability, formulary coverage, individual tolerability, and prescriber familiarity rather than definitive comparative efficacy data

doi: 10.1038/s43587-021-00082-y 41 MehdizadehMAguilarMThorinEFerbeyreGNattelS