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Collectively, these results suggest that cinchonine is a potential GLP-1R agonist

A novel gastric pentadecapeptide bpc 157 with different beneficial activities and anticonvulsant effect interacting with gabaergic system could improve diazepam efficacy coadministered (10 microg/kg, 10 ng/kg i.p.) with diazepam (5.0 mg/kg i.p.) twice daily for 10 days, since diazepam chronic medication would otherwise predispose for diazepam- tolerance/withdrawal development (shorter latency to convulsion after convulsant)

However, most evidence comes from animal models or small human trials

To construct the combinatorial peptide libraries, the Exendin 939 (Ex 939) antagonist as anchor site to GLP-1R extracellular domain was kept constant