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Drucker says its important to acknowledge when GLP-1s fall short in clinical trials

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Moreover, the chemical nature of the C-terminal residue side chain determines ligand contact with RAMP and can influence activity at AMYRs and CTR 18,19

Cardiovascular outcome trials have further demonstrated that GLP-1 agonists like semaglutide reduce major adverse cardiac events in patients with established heart disease or diabetes

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Patients should not restart tirzepatide and should contact their healthcare team if they experience: inability to keep fluids down for more than 4-6 hours, persistent vomiting for more than 24 hours, severe abdominal pain, or blood glucose levels consistently above 300 mg/dL