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Figure 3 Conclusions DPP-4 inhibitors are important oral antidiabetic agents that are placed as second-line therapy after metformin failure as insulinotropic agents that have no intrinsic hypoglycaemia risk and are body weight neutral

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Additionally, HIF-1 acts as a master regulator of oxygen homeostasis in cellular metabolism by directly controlling the expression and activity of pyruvate kinase muscle isozyme 2 (PKM2), which drives metabolic reprogramming in CSCs