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[3] Like NADH, NADPH is fluorescent
Additionally, GLP-1 RAs with established CV benefitsspecifically liraglutide, subcutaneous semaglutide, dulaglutide, and efpeglenatideare recommended for patients with T2DM and ASCVD to reduce CV events, regardless of baseline or target HbA1c levels or concurrent glucose-lowering therapy (Class I, LoE A)
At the GLP-1 receptor, Tirzepatide activates pathways associated with glycaemic control, gastric emptying, and appetite-related signalling in preclinical models
For AD specifically, given the well-established effects of GLP-1 RAs on tau hyperphosphorylation, we recommend that future GLP-1 RA clinical trials focus on the tau-positive subgroup of patients
Further research is needed to establish the exact chemical nature of available compounded GLP-1 products