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According to the Ozempic Patient Information Leaflet (PIL), after first use, the pen may be stored at room temperature (below 30C) or in a refrigerator for up to 6 weeks

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The treatment was safe and well tolerated [86]

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Smad signaling is attenuated by inhibitory Smads (I-Smads, Smad6 and Smad7), dephosphorylation and dissociation from the trimeric complex, allowing for either Smad recycling or degradation (106)

Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: Toward pathophysiological delineation of diabetes mellitus-related osteoarthritis