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The three most highly ranked candidates within this category were glutathione- S -transferase omega-1 (GSTO1

Because SAM is required for hundreds of methylation reactions, including those that build creatine and glutathione, low levels of SAM can ripple across nearly every body system

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Originally discovered inside of a volcano on Easter Island (a.k.a Rapa Nui), rapamycin is widely known for mimicking the effects of caloric restriction, one of the most tried and tested methods shown to increase the lifespan of multiple model organisms

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10.1016/j.ejps.2011.09.019 62 JiaQ.ZhuR.TianY.ChenB.LiR.LiL.et al (2019)