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In the Falutz 2010 trials, once-daily dosing at 2 mg produced mean IGF-1 increases that normalized toward baseline over the 26-week trial, suggesting some receptor adaptation without complete desensitization

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Aziz F, Tripolt NJ, Pferschy PN, et al

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The peptide represents a modified version of amino acids 176-191 from the C-terminal region of human growth hormone, with a tyrosine addition at the N-terminus for stability