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It's the chronic, 24/7 elevation of GH (as seen in certain medical conditions or with improper use of exogenous GH) that poses a much more formidable threat to long-term metabolic health

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it might be difficult for them to effectively cross the skin due to poor permeability 23

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showed that changes in SDC-1 mechanical tension generate a tension gradient in SDC-1 under fluid shear force, with SDC-1 interacting differently with the cytoskeleton depending on substrate stiffness, affecting integrin-mediated signaling and focal adhesion formation [49]

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