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Pharmaceutical versions of GLP-1, such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound), were initially developed to treat type 2 diabetes but are now widely prescribed for weight loss and other health conditions
Fortunately Habener knew this could be sourced from anglerfish from his earlier work with Potts and Rich (Majzoub, Kronenberg, Potts)
Both are likely to require either significant real world observation in off-label use, or some form of RCT with careful observation
doi: 10.1111/jcpt.13259 65 AlvesCBatel-MarquesFMacedoAF
Bruising occurs when small blood vessels are disrupted, while repeatedly injecting in the same area can lead to thickened fatty tissue forming lumps
Combination therapy (ixekizumab + tirzepatide) showed a clear advantage, with nearly one-third of patients achieving the primary endpoint compared to less than 1% with ixekizumab alone
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