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Another potential limitation in drawing conclusions about genotype-phenotype associations is the small number of patients recruited in many of the referenced studies

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201 Dysregulation of IL-17 signaling disrupts epidermal homeostasis through activation of the NF-B pathway, concurrently exacerbating systemic inflammatory cascades

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Besides, gp120 induces secretion of tumor necrosis factor- (TNF-) and monocyte chemoattractant protein-1 (MCP-1), leading to neuronal cell death, subsequently [40]