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According to a Rybelsus trial published in the The New England Journal of Medicine: 44% of users reported nausea 32% of users reported diarrhea Key takeaway Early evidence showed that Pfizers new oral GLP-1 receptor agonist danuglipron showed similar results to Novos Ozempic without the need for injection, and to its oral formulation Rybelsus without the need for fasting restrictions

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For example, Semaglutide GLP-1, with its extended half-life and once-weekly dosing schedule, might be more convenient for patients who have difficulty remembering to take daily medication

Each of the criteria was scored semiquantitatively as 0: none