In the AWARD-7 trial (which was not a CVOT) performed in T2DM subjects with moderate-to-severe CKD, onceweekly dulaglutide produced glycemic control similar to that achieved with insulin glargine, but showed evidence of reduced decline in eGFR (64)
This result is in accordance with a previous report that a GLP-1 analog (exendin-4) enhanced excitatory synaptic transmission through AMPA receptors trafficking in the PVN CRH neurons (16) (Figure 1, G and H)
Injection Site Rotation Strategy and Timing Site rotation prevents lipohypertrophy, a thickening of fatty tissue that can develop from repeated injections in identical locations
Contamination is insidious
Choosing between semaglutide and tirzepatide depends on several factors, including how a patients body responds, the presence of diabetes, and tolerance to side effects
This represents an intermediate step between Wiesner nevus (also known as BAPoma) and melanoma carrying inactivating BAP1 mutations