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10.1021/acs.chemrestox.6b00291 71 NazmyE

Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes

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Reduced RORA expression was detected alongside that of superoxide dismutase and G protein-coupled estrogen receptor-1 genes, as well as upregulated progesterone receptor expression

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This enzymatic action depletes the available intracellular pool of nicotinamide, directly limiting the synthesis of nicotinamide adenine dinucleotide (NAD+)