Time is your friend the receptors are not going anywhere
Tau accumulation and its association with neurodegeneration and cognitive impairments demonstrated in the current study were reported in several previous animal 60,68,72 and in clinical studies, where total tau (t-tau) and p-tau have been recognized as essential biomarkers for AD and have undergone successful validation through controlled, large-scale, multicenter studies 80
Blood levels are approaching but haven't yet reached steady state
The lack of incorporation of the cardiovascular benefits of oral semaglutide, empagliflozin and dulaglutide observed in cardiovascular outcomes trials (CVOTs) could also be seen as a limitation of the analysis
"Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects." The Journal of Clinical Endocrinology & Metabolism 81.12 (1996): 4249-4257
Green frogs live wherever shallow freshwater ponds, road-side ditches, lakes, swamps, streams, and brooks are found
